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Pittsburgh vs. Virginia odds, line, spread: 2021 college football picks, Week 12 predictions from proven model

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The Virginia Cavaliers and the Pittsburgh Panthers will face off in an ACC clash at 3:30 p.m. ET on Saturday, November 20 at Heinz Field in Pittsburgh. Pitt is 8-2 overall and 4-2 at home, while the Cavaliers are 6-4 overall and 2-2 on the road. It’s a battle for first place in the ACC Coastal division and leading into the game everybody is keeping a close eye on the status of Virginia quarterback Brennan Armstrong. Armstrong missed last week’s game with a rib injury, but Pitt head coach Pat Narduzzi says he is preparing for Armstrong to play and a high-profile QB battle against Kenny Pickett could make for one of the most exciting matchups of the week. 

Pitt is favored by 14.5 points in the latest Pittsburgh vs. Virginia odds from Caesars Sportsbook, and the over-under is set at 66. Before making any Virginia vs. Pittsburgh picks, you’ll want to see the college football predictions and betting advice from the red-hot model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 12 of the 2021 season on a 36-23 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

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Now, the model has set its sights on Pittsburgh vs. Virginia and it just locked in its coveted CFB picks and predictions. You can head to SportsLine now to see its picks. Here are several college football odds and betting lines for Pittsburgh vs. Virginia:

  • Pittsburgh vs. Virginia spread: Pittsburgh -14.5
  • Pittsburgh vs. Virginia over-under: 66 points

Featured Game | Pittsburgh Panthers vs. Virginia Cavaliers

What you need to know about Pittsburgh

It may have taken overtime to finish the job, but Pitt ultimately got the result they were hoping for on Thursday with a 30-23 win over the North Carolina Tar Heels. It was another big night for Pitt’s QB Kenny Pickett, who passed for three TDs and 347 yards on 44 attempts.

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After three relatively average seasons as the starter at Pitt, Pickett has taken his game to another level and his in the thick of the Heisman Trophy conversation with 3,517 passing and 32 touchdowns against just four interceptions while adding 223 yards and four more scores on the ground. He should be in for another big day against a Virginia defense that has given up 1,627 yards and 134 points the last three weeks.

What you need to know about Virginia

Meanwhile, a victory for Virginia just wasn’t in the stars on Saturday as the squad never even grasped a temporary lead. They suffered a grim 28-3 defeat to the Notre Dame Fighting Irish. Quarterback Jay Woolfolk struggled with Brennan Armstrong out, throwing for just 196 yards and two interceptions.

However, we know that Virginia’s passing attack can be devastating if Armstrong is healthy enough to play. The second-year starter has thrown for 3,557 yards and 27 touchdowns against eight interceptions in nine games this season and he’s also mobile enough to cause issues with his legs, rushing for 271 yards and seven scores in 2021.

How to make Pittsburgh vs. Virginia picks

The model has simulated Pittsburgh vs. Virginia 10,000 times and the results are in. We can tell you that the model is leaning under on the point total and it’s also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the model’s Pitt vs. Virginia pick at SportsLine.

So who wins Virginia vs. Pittsburgh? And which side of the spread hits well over 50 percent of the time? Visit SportsLine now to see which side of the spread you need to be all over, all from the model that has crushed its college football picks, and find out.

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How to watch Appalachian State vs. James Madison: NCAA Football live stream info, TV channel, time, game odds

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Who’s Playing

James Madison @ Appalachian State

Current Records: James Madison 2-0; Appalachian State 2-1

What to Know

The James Madison Dukes watched the action from their couches last weekend, but are set to take to the field. James Madison and the Appalachian State Mountaineers will face off in a Sun Belt battle at 3:30 p.m. ET Saturday at Kidd Brewer Stadium. The odds don’t look promising for the Dukes, but the bigger the opponent is, the harder they fall.

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A well-balanced attack led James Madison over the Norfolk State Spartans every single quarter on their way to victory two weeks ago. James Madison claimed a resounding 63-7 win over Norfolk State at home. The game was pretty much decided by the half, when the score had already reached 35 to nothing.

Meanwhile, Appalachian State didn’t have too much breathing room in their contest with the Troy Trojans last week, but they still walked away with a 32-28 victory. Appalachian State QB Chase Brice was slinging it as he passed for two TDs and 279 yards on 34 attempts. Near the top of the highlight reel was Brice’s 53-yard TD bomb to WR Christan Horn in the fourth quarter.

Their wins bumped the Dukes to 2-0 and the Mountaineers to 2-1. Watch the matchup and check back on CBS Sports to find out who keeps up the positive energy and who hits a stumbling block.

How To Watch

  • When: Saturday at 3:30 p.m. ET
  • Where: Kidd Brewer Stadium — Boone, North Carolina
  • TV: ESPN Plus
  • Online streaming: fuboTV (Try for free. Regional restrictions may apply.)
  • Follow: CBS Sports App
  • Ticket Cost: $40.99

Odds

The Mountaineers are a solid 6.5-point favorite against the Dukes, according to the latest college football odds.

The oddsmakers had a good feel for the line for this one, as the game opened with the Mountaineers as a 7.5-point favorite.

Over/Under: -111

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See college football picks for every single game, including this one, from SportsLine’s advanced computer model. Get picks now.

Series History

This is the first time these teams have played each other within the last seven years.



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UTSA vs. Texas Southern: How to watch NCAA Football online, TV channel, live stream info, game time

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Who’s Playing

Texas Southern @ UTSA

Current Records: Texas Southern 1-2; UTSA 1-2

What to Know

The Texas Southern Tigers will take on the UTSA Roadrunners at 3:30 p.m. ET Saturday at Alamodome. Texas Southern isn’t favored, but they just beat the odds in their last game, so don’t count them out.

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The Tigers kept a clean sheet against the Southern University Jaguars last week and took the matchup 24 to nothing. The squad ran away with 21 points in the first half and mostly just sat on those in the second to pick up the victory.

Meanwhile, it was all tied up 17-17 at halftime, but UTSA was not quite the Texas Longhorns’ equal in the second half when they met last week. The Roadrunners suffered a grim 41-20 defeat to the Longhorns. This contest was a close 17-17 at the break, but unfortunately for UTSA it sure didn’t stay that way. A silver lining for them was the play of RB Brenden Brady, who threw one touchdown in addition to punching in one rushing touchdown.

Texas Southern’s win lifted them to 1-2 while UTSA’s loss dropped them down to 1-2. We’ll find out if the Tigers can add another positive mark to their record or if UTSA can shake off the defeat and take the spring out of Texas Southern’s step.

How To Watch

  • When: Saturday at 3:30 p.m. ET
  • Where: Alamodome — San Antonio, Texas
  • TV: STADIUM
  • Follow: CBS Sports App
  • Ticket Cost: $69.00

Odds

The Roadrunners are a big 42-point favorite against the Tigers, according to the latest college football odds.

Bettors have moved against the Roadrunners slightly, as the game opened with the Roadrunners as a 44-point favorite.

Over/Under: -110

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See college football picks for every single game, including this one, from SportsLine’s advanced computer model. Get picks now.

Series History

This is the first time these teams have played each other within the last seven years.



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North Carolina vs. Notre Dame live stream info, TV channel: How to watch NCAA Football on TV, stream online

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Who’s Playing

Notre Dame @ North Carolina

Current Records: Notre Dame 1-2; North Carolina 3-0

What to Know

The North Carolina Tar Heels will be returning home after a two-game road trip. They will take on the Notre Dame Fighting Irish at 3:30 p.m. ET Saturday at Kenan Memorial Stadium after a week off. UNC is expected to win — but not by much — so they will need to come into the game prepared for a fight.

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The Tar Heels beat the Georgia State Panthers 35-28 two weeks ago. Among those leading the charge for UNC was RB Omarion Hampton, who rushed for two TDs and 110 yards on 16 carries. Hampton put himself on the highlight reel with a 58-yard TD scramble in the third quarter.

Meanwhile, Notre Dame netted a 24-17 victory over the California Golden Bears last week. RB Audric Estime and RB Chris Tyree were among the main playmakers for Notre Dame as the former punched in one rushing touchdown and the latter snatched one receiving TD.

Notre Dame’s defense was a presence as well, as it embarrassed California’s offensive line to sack QB Jack Plummer six times for a total loss of 47 yards. It was a group effort with four guys contributing.

The wins brought the Tar Heels up to 3-0 and the Fighting Irish to 1-2. A pair of stats to keep an eye on: UNC enters the matchup with 310 passing yards per game on average, good for 21st best in the nation. But Notre Dame comes into the contest boasting the 34th fewest passing yards allowed per game in the nation at 184. These opposing strengths should make for an exciting matchup.

How To Watch

  • When: Saturday at 3:30 p.m. ET
  • Where: Kenan Memorial Stadium — Chapel Hill, North Carolina
  • TV: ABC
  • Online streaming: fuboTV (Try for free. Regional restrictions may apply.)
  • Follow: CBS Sports App
  • Ticket Cost: $110.00

Odds

The Tar Heels are a slight 2.5-point favorite against the Fighting Irish, according to the latest college football odds.

The line on this game has moved quite a bit since it opened, as it started out with the Fighting Irish as a 1.5-point favorite.

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Over/Under: -110

See college football picks for every single game, including this one, from SportsLine’s advanced computer model. Get picks now.

Series History

Notre Dame have won all of the games they’ve played against North Carolina in the last eight years.

  • Oct 30, 2021 – Notre Dame 44 vs. North Carolina 34
  • Nov 27, 2020 – Notre Dame 31 vs. North Carolina 17
  • Oct 07, 2017 – Notre Dame 33 vs. North Carolina 10



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