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Oklahoma vs. Iowa State odds, line: 2021 college football picks, Week 12 predictions from model on 36-23 run

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The Oklahoma Sooners lost just once in 47 meetings with the Iowa State Cyclones from 1962-2016 before settling for a split of their next four matchups, including a 37-30 setback on the road last season. Oklahoma avenged that defeat in the Big 12 Conference title game, however, as it posted a 27-21 victory to capture its sixth consecutive conference crown. The 13th-ranked Sooners hope to begin another winning streak in the all-time series when they host the Cyclones on Saturday. Oklahoma owns a 77-7-2 record against Iowa State, including a 39-4-1 mark at home.

Kickoff at Memorial Stadium in Norman, Okla., is set for noon ET. The Sooners are 3.5-point favorites in the latest Oklahoma vs. Iowa State odds from Caesars Sportsbook, while the over-under for total points scored is 59.5. Before locking in any Iowa State vs. Oklahoma picks and college football predictions, you need to see what the SportsLine Projection Model has to say.

The model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 12 of the 2021 season on a 36-23 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

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Now, the model has set its sights on Oklahoma vs. Iowa State and just locked in its CFB picks and predictions. You can visit SportsLine now to see the model’s picks. Here are the college football odds and betting lines for Iowa State vs. Oklahoma:

  • Oklahoma vs. Iowa State spread: Sooners -3.5
  • Oklahoma vs. Iowa State over-under: 59.5 points 
  • Oklahoma vs. Iowa State money line: Sooners -170, Cyclones +145 
  • OKLA: The Sooners are 5-0 against the spread in their last five home games against teams with winning records 
  • ISU: The Cyclones are 5-1 ATS in their last six meetings with the Sooners

Featured Game | Oklahoma Sooners vs. Iowa State Cyclones

Why Oklahoma can cover

Losing back-to-back regular-season games is a rare occurrence for the Sooners as they are 41-1 following a setback since 1999, when they were defeated 38-28 by Texas after falling 34-30 at Notre Dame a week earlier. Oklahoma looks to put last week’s 27-14 loss at Baylor in the rearview mirror and get back in the win column behind its offense. The Sooners scored 35 or more points in five straight contests prior to the loss to the Bears, producing at least 52 three times in that span, and lead the Big 12 while ranking 17th in the nation with an average of 455.3 yards per game.

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Freshman quarterback Caleb Williams has completed 82-of-117 pass attempts for 1,233 yards with 14 touchdowns and three interceptions in his last five games while also rushing for 244 yards and four scores, including three of 40 or more yards. In that same span, Kennedy Brooks has averaged 107.8 rushing yards while running for six TDs. The redshirt junior, who sat out the 2020 season due to coronavirus concerns, has found the end zone in 11 of his last 13 games dating back to 2019 and needs 143 yards to join De’Mond Parker (1996-98), Adrian Peterson (2004-06) and Samaje Perine (2014-16) as the only Sooners to record three 1,000-yard seasons.

Why Iowa State can cover

The Cyclones have averaged 36.5 points over their last eight games, scoring 30 or more six times in that span. They also have racked up 459.1 yards of total offense during that stretch and eclipsed 400 in all but one contest. Senior Brock Purdy recorded season highs of 32 completions and 356 yards last week, giving him 2,441 passing yards on the year — second-most in the conference.

Purdy was 32-of-42 (76.2 percent) against the Red Raiders, marking the nation-leading sixth time this season he has completed more than 75 percent of his pass attempts. Meanwhile, Breece Hall rushed for a pair of touchdowns in the loss to extend his streak to 22 consecutive games with at least one score on the ground. The junior has had a TD run in 24 of his last 25 games dating back to 2019 and is tied for fourth in the country with 16 this campaign.

How to make Oklahoma vs. Iowa State picks

SportsLine’s model is leaning over on the total, projecting 64 combined points. It also has generated an against-the-spread pick that cashes in well over 50 percent of simulations. You can only get the model’s Iowa State vs. Oklahoma pick at SportsLine.

So who wins Iowa State vs. Oklahoma? And which side of the spread hits well over 50 percent of the time? Visit SportsLine now to see which side of the Oklahoma vs. Iowa State spread to back, all from the advanced model that is up almost $3,500 on its top-rated college football spread picks, and find out.

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How to watch Appalachian State vs. James Madison: NCAA Football live stream info, TV channel, time, game odds

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Who’s Playing

James Madison @ Appalachian State

Current Records: James Madison 2-0; Appalachian State 2-1

What to Know

The James Madison Dukes watched the action from their couches last weekend, but are set to take to the field. James Madison and the Appalachian State Mountaineers will face off in a Sun Belt battle at 3:30 p.m. ET Saturday at Kidd Brewer Stadium. The odds don’t look promising for the Dukes, but the bigger the opponent is, the harder they fall.

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A well-balanced attack led James Madison over the Norfolk State Spartans every single quarter on their way to victory two weeks ago. James Madison claimed a resounding 63-7 win over Norfolk State at home. The game was pretty much decided by the half, when the score had already reached 35 to nothing.

Meanwhile, Appalachian State didn’t have too much breathing room in their contest with the Troy Trojans last week, but they still walked away with a 32-28 victory. Appalachian State QB Chase Brice was slinging it as he passed for two TDs and 279 yards on 34 attempts. Near the top of the highlight reel was Brice’s 53-yard TD bomb to WR Christan Horn in the fourth quarter.

Their wins bumped the Dukes to 2-0 and the Mountaineers to 2-1. Watch the matchup and check back on CBS Sports to find out who keeps up the positive energy and who hits a stumbling block.

How To Watch

  • When: Saturday at 3:30 p.m. ET
  • Where: Kidd Brewer Stadium — Boone, North Carolina
  • TV: ESPN Plus
  • Online streaming: fuboTV (Try for free. Regional restrictions may apply.)
  • Follow: CBS Sports App
  • Ticket Cost: $40.99

Odds

The Mountaineers are a solid 6.5-point favorite against the Dukes, according to the latest college football odds.

The oddsmakers had a good feel for the line for this one, as the game opened with the Mountaineers as a 7.5-point favorite.

Over/Under: -111

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See college football picks for every single game, including this one, from SportsLine’s advanced computer model. Get picks now.

Series History

This is the first time these teams have played each other within the last seven years.



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UTSA vs. Texas Southern: How to watch NCAA Football online, TV channel, live stream info, game time

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Who’s Playing

Texas Southern @ UTSA

Current Records: Texas Southern 1-2; UTSA 1-2

What to Know

The Texas Southern Tigers will take on the UTSA Roadrunners at 3:30 p.m. ET Saturday at Alamodome. Texas Southern isn’t favored, but they just beat the odds in their last game, so don’t count them out.

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The Tigers kept a clean sheet against the Southern University Jaguars last week and took the matchup 24 to nothing. The squad ran away with 21 points in the first half and mostly just sat on those in the second to pick up the victory.

Meanwhile, it was all tied up 17-17 at halftime, but UTSA was not quite the Texas Longhorns’ equal in the second half when they met last week. The Roadrunners suffered a grim 41-20 defeat to the Longhorns. This contest was a close 17-17 at the break, but unfortunately for UTSA it sure didn’t stay that way. A silver lining for them was the play of RB Brenden Brady, who threw one touchdown in addition to punching in one rushing touchdown.

Texas Southern’s win lifted them to 1-2 while UTSA’s loss dropped them down to 1-2. We’ll find out if the Tigers can add another positive mark to their record or if UTSA can shake off the defeat and take the spring out of Texas Southern’s step.

How To Watch

  • When: Saturday at 3:30 p.m. ET
  • Where: Alamodome — San Antonio, Texas
  • TV: STADIUM
  • Follow: CBS Sports App
  • Ticket Cost: $69.00

Odds

The Roadrunners are a big 42-point favorite against the Tigers, according to the latest college football odds.

Bettors have moved against the Roadrunners slightly, as the game opened with the Roadrunners as a 44-point favorite.

Over/Under: -110

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See college football picks for every single game, including this one, from SportsLine’s advanced computer model. Get picks now.

Series History

This is the first time these teams have played each other within the last seven years.



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North Carolina vs. Notre Dame live stream info, TV channel: How to watch NCAA Football on TV, stream online

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Who’s Playing

Notre Dame @ North Carolina

Current Records: Notre Dame 1-2; North Carolina 3-0

What to Know

The North Carolina Tar Heels will be returning home after a two-game road trip. They will take on the Notre Dame Fighting Irish at 3:30 p.m. ET Saturday at Kenan Memorial Stadium after a week off. UNC is expected to win — but not by much — so they will need to come into the game prepared for a fight.

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The Tar Heels beat the Georgia State Panthers 35-28 two weeks ago. Among those leading the charge for UNC was RB Omarion Hampton, who rushed for two TDs and 110 yards on 16 carries. Hampton put himself on the highlight reel with a 58-yard TD scramble in the third quarter.

Meanwhile, Notre Dame netted a 24-17 victory over the California Golden Bears last week. RB Audric Estime and RB Chris Tyree were among the main playmakers for Notre Dame as the former punched in one rushing touchdown and the latter snatched one receiving TD.

Notre Dame’s defense was a presence as well, as it embarrassed California’s offensive line to sack QB Jack Plummer six times for a total loss of 47 yards. It was a group effort with four guys contributing.

The wins brought the Tar Heels up to 3-0 and the Fighting Irish to 1-2. A pair of stats to keep an eye on: UNC enters the matchup with 310 passing yards per game on average, good for 21st best in the nation. But Notre Dame comes into the contest boasting the 34th fewest passing yards allowed per game in the nation at 184. These opposing strengths should make for an exciting matchup.

How To Watch

  • When: Saturday at 3:30 p.m. ET
  • Where: Kenan Memorial Stadium — Chapel Hill, North Carolina
  • TV: ABC
  • Online streaming: fuboTV (Try for free. Regional restrictions may apply.)
  • Follow: CBS Sports App
  • Ticket Cost: $110.00

Odds

The Tar Heels are a slight 2.5-point favorite against the Fighting Irish, according to the latest college football odds.

The line on this game has moved quite a bit since it opened, as it started out with the Fighting Irish as a 1.5-point favorite.

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Over/Under: -110

See college football picks for every single game, including this one, from SportsLine’s advanced computer model. Get picks now.

Series History

Notre Dame have won all of the games they’ve played against North Carolina in the last eight years.

  • Oct 30, 2021 – Notre Dame 44 vs. North Carolina 34
  • Nov 27, 2020 – Notre Dame 31 vs. North Carolina 17
  • Oct 07, 2017 – Notre Dame 33 vs. North Carolina 10



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