We’re two weeks into the 2022 NFL season, and already we have an idea of which teams might be headed for a serious title run — none better than the dominant Buffalo Bills. Even so, upsets and comebacks are a weekly ingredient on the NFL schedule. So it’s anyone’s guess as to how Week 3 will unfold, especially with a handful of potential playoff previews on the docket.

Thankfully, the experts at CBS Sports and SportsLine have you covered. Each week, we collect all of their best picks and betting advice in one place, so you can get picks against the spread from our experts as well as additional feature content for each game, including plays from top SportsLine experts and the SportsLine Projection Model, best bets from our staff, survivor picks and more.

All NFL odds via Caesars Sportsbook.

Which picks can you make with confidence in Week 3? And which Super Bowl contender goes down hard? Visit SportsLine, as its incredible model simulates every NFL game 10,000 times and is up more than $7,500 for $100 players on top-rated NFL picks since its inception.

Jacksonville Jaguars at Los Angeles Chargers

Time: Sunday, 4:05 p.m. ET (CBS), stream on Paramount+ (click here)  
Open: Chargers -3, O/U 42.5

The Jaguars are riding high after blowing out the rival Colts in Week 2, and Trevor Lawrence finally seems to be coming out of his shell as a Doug Pederson disciple. But this feels like “a little bit of a letdown spot,” Tyler Sullivan noted on the “Pick Six NFL Podcast” this week. The Chargers are coming off 10 days of rest, Jacksonville is traveling from coast to coast, and L.A. should be motivated to rebound following a tough AFC West loss in Week 2. Even if Justin Herbert’s injured ribs force Chase Daniel under center (and the line inevitably drops), Sully is sold on the Chargers in this spot.

For more analysis and Week 3 picks from the “Pick Six” crew, check out the podcast right here.

Los Angeles Rams at Arizona Cardinals

Time: Sunday, 4:25 p.m. ET (Fox), stream on fuboTV (try for free)
Open: Rams -3.5, O/U 48.5

Featured Game | Arizona Cardinals vs. Los Angeles Rams

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“The Cardinals have zero business sitting at 1-1 right now. Kyler Murray running around like a maniac on fourth down and making miracle plays is simply unsustainable. The Rams are being downgraded publicly because of Week 1’s blasting by the Bills and then narrowly squeaking by the Falcons last week. But they took care of business against Atlanta before shenanigans happened and Buffalo just might be a buzz saw. The Cardinals are shorthanded at wide receiver and the Rams have the sort of superstars to slow down Kyler and limit this passing attack.”

Will Brinson is all over the Rams as big favorites even in a divisional game. Find all of his Week 3 picks right here.

Atlanta Falcons at Seattle Seahawks

Time: Sunday, 4:25 p.m. ET (Fox), stream on fuboTV (try for free)
Open: Seahawks -1, O/U 42

Featured Game | Seattle Seahawks vs. Atlanta Falcons

“The Falcons have been plucky to begin the season, owning a 2-0 ATS record. A special teams snafu by the Rams — a blocked punt returned for a Falcons touchdown — did bring Atlanta back to life with a cover, but the team still moved the ball well offensively and hasn’t even begun to scratch the surface of utilizing star tight end Kyle Pitts. This week, the Falcons get their easiest opponent of the season thus far in the Seahawks, despite this game being played on the road at Lumen Field. While Seattle was able to upset the Broncos in an emotional opener, Geno Smith and the rest of the offense don’t exactly strike fear in opposing defenses. They’ve also struggled against the run, ranking 28th in the NFL in DVOA.”

Tyler Sullivan likes the Falcons not only to keep it close against Seattle but beat the Seahawks in their own stadium. You can find all of his Week 3 picks at CBS Sports right here.

Green Bay Packers at Tampa Bay Buccaneers

Time: Sunday, 4:25 p.m. ET (Fox), stream on fuboTV (try for free)  
Open: Buccaneers -1, O/U 42

Featured Game | Tampa Bay Buccaneers vs. Green Bay Packers

Before you lock in any picks for what could be the last-ever Aaron Rodgers-Tom Brady matchup, you’ll wanna check in with SportsLine’s advanced projection model, which is on a 139-102 run making top-rated NFL picks since 2017. More accurate than 94% of CBS Sports Football Pick’em players four times during that span, the model has reason to trust Brady, even with limited weapons. The ageless QB has two or more TD passes in 13 of his 16 home starts with Tampa Bay, and he’s had five straight starts against Green Bay with a passer rating of 95 or better.

We can tell you the model is leaning Under the total, and one side of this matchup is winning 60% of simulations. Find out which team to back, and more SportsLine analysis on this matchup, right here.

San Francisco 49ers at Denver Broncos

Time: Sunday, 8:20 p.m. ET (NBC), stream on fuboTV (try for free)
Open: 49ers -1.5, O/U 44

Featured Game | Denver Broncos vs. San Francisco 49ers

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The 49ers are transitioning at quarterback (again), this time with Jimmy Garoppolo back under center in place of Trey Lance. But Tom Fornelli, who’s 17-6 in his picks involving San Francisco, is particularly encouraged by the Niners defense going into Week 3: San Francisco leads the NFL in total defense, giving up 210 yards and only 13 points per game. The 49ers also lead the league in first downs allowed and passing yards allowed, whereas the Broncos have been sloppy moving the ball.

We can tell you Fornelli is leaning Under the total, but to see his ATS pick for Broncos-49ers, head on over to SportsLine.

Dallas Cowboys at New York Giants

Time: Monday, 8:15 p.m. ET (ESPN), stream on fuboTV (try for free)
Open: Cowboys -1, O/U 39

Featured Game | New York Giants vs. Dallas Cowboys

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Brian Daboll has inspired the New York fan base after two gutsy wins, giving the Giants a surprise 2-0 start. Is it possible Big Blue can make it three straight in prime time? Cooper Rush will remain under center for the Cowboys, who are still missing Dak Prescott but fought hard to upset the reigning AFC champion Bengals in Week 2. The real question is, whose defense will make more noise under the lights? Dallas has maybe the best pass rusher in the game in Micah Parsons, while the G-Men will be adding reinforcements off the edge and have been especially feisty under Wink Martindale.

SportsLine expert R.J. White is 445-378-24 on ATS picks since 2017, and he’s got a full breakdown and ATS pick for “Monday Night Football” on SportsLine, right here.