The Tampa Bay Buccaneers will take on the Indianapolis Colts at 1 p.m. ET on Sunday at Lucas Oil Stadium. Indianapolis is 6-5 overall and 3-3 at home, while the Buccaneers are 7-3 overall and 2-3 on the road. Tampa Bay avoided a third straight loss in Week 11. The Colts have won five of their last six games. 

Buccaneers coach Bruce Arians is 3-0 vs. the Colts. Tampa Bay is favored by three points in the latest Colts vs. Buccaneers odds from Caesars Sportsbook, and the over-under is set at 53. Before entering any Buccaneers vs. Colts picks, you’ll want to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up almost $7,300 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 12 of the 2021 season on an incredible 130-91 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Colts vs. Buccaneers. You can head to SportsLine to see its picks. Here are several NFL betting lines for Colts vs. Buccaneers:

• Colts vs. Buccaneers spread: Colts +3
• Colts vs. Buccaneers over-under: 53 points

What you need to know about the Colts

Last week, the Colts rolled into Buffalo and came away with a surprisingly dominant 41-15 win, their third consecutive victory. Jonathan Taylor had 204 scrimmage yards (185 rushing) and career-high five TDs (four rushing) last week. He became the first player ever with 175-plus rush yards, four-plus rushing TDs, and a receiving TD in a single game. Taylor leads the NFL with 1,444 scrimmage yards (1,122 rushing) and 15 TDs (13 rushing).

The Colts lead the league in turnover differential at +15. Kwity Paye had a sack and a forced fumble in Week 11. Darius Leonard (ankle) is questionable for Week 12. 

What you need to know about the Buccaneers

The Buccaneers strolled past the New York Giants last week, 30-10. Tom Brady passed for 307 yards and two TDs. He leads the NFL with 29 TD passes and is tied for the most 300-yard games with five. Mike Evans caught his 10th TD pass and is tied for the league lead. 

Chris Godwin has five-plus catches in his last six games. Vita Vea (knee) and Devin White (quadriceps) are questionable for Sunday’s game. Ali Marpet (oblique) is doubtful and Antonio Brown (ankle) remains out. 

How to make Colts vs. Buccaneers picks

The model has simulated Colts vs. Buccaneers 10,000 times and the results are in. We can tell you that the model is leaning Over, and it’s also generated a point-spread pick that is hitting in 60 percent of simulations. You can only see the pick at SportsLine.

So who wins Colts vs. Buccaneers? And which side of the spread hits 60 percent of the time? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.