The Week 12 college football schedule brings one matchup with enormous College Football Playoff implications for both teams. No. 4 Ohio State vs. No. 7 Michigan State at noon ET on Saturday pits two of the Big Ten’s three one-loss teams against each other. Ohio State is a 19-point favorite in this one, according to the Week 12 college football odds at Caesars Sportsbook.

That spread is similar to the 21-point margin No. 2 Alabama’s favored by against No. 21 Arkansas in the 3:30 p.m. ET SEC on CBS Saturday matchup. Which side should you be on in those and other Week 12 college football spreads? Before making any Week 12 college football picks, be sure to see the latest college football predictions and betting advice from SportsLine’s proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 12 of the 2021 season on a 36-23 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 12 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top Week 12 college football predictions

One of the top college football picks the model is recommending for Week 12: No. 18 Pittsburgh (-13.5) covers at home against Virginia in a 3:30 p.m. ET ACC matchup. The Cavaliers have a high-octane offense powered by quarterback Brennan Armstrong, but Armstrong (ribs) is uncertain for this one. The model is siding with signal-caller Kenny Pickett and the Panthers. The Panthers have regularly topped Vegas expectations as they are 7-2 against the spread this season. 

The model shows Pickett operating another smooth game for Pitt’s offense and getting almost 350 yards through the air with at least two touchdowns. In simulations, Pitt takes home the win and covers well over 50 percent of the time. The under 66 also hits in almost 60 percent of simulations, making this game an intriguing parlay possibility. 

Another one of the college football predictions from the model: No. 6 Michigan (-14.5) covers the two-score spread at Maryland in a 3:30 p.m. ET Big Ten battle. The Wolverines have bounced back from their loss at Michigan State with consecutive wins over Indiana and Penn State. They have now notched blowout victories over Wisconsin, Northwestern and Indiana in conference play. Michigan cannot afford another loss, so it will be motivated from the opening kick-off in Saturday’s matchup.

Maryland has now lost five of its last six games, with all those setbacks coming by at least 17 points. The Terrapins did not score more than 21 points in any of those game. SportLine’s model does not have Maryland cracking 20 points on Saturday, resulting in Michigan covering the spread in over 60 percent of simulations. 

How to make Week 12 college football picks 

The model has also made the call on who wins and covers in every other game on the Week 12 college football schedule, and it’s calling for an upset that will have a big impact on the College Football Playoff chase. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which underdog do you need to jump on now? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,500 in profit over the past five-plus seasons, and find out.

Week 12 college football odds (via Caesars)

Here are the college football lines for some of Week 12’s most notable matchups:

Thursday, Nov. 18

Louisville vs. Duke (+19.5, 59)

Friday, Nov. 19

Southern Mississippi vs. Louisiana Tech (-16.5, 51.5)

Featured Game | Louisiana Tech Bulldogs vs. Southern Miss Golden Eagles

Memphis vs. Houston (-9.5, 60.5)

Featured Game | Houston Cougars vs. Memphis Tigers

Arizona vs. Washington State (-15, 52.5)

Featured Game | Washington State Cougars vs. Arizona Wildcats

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Air Force vs. Nevada (-2, 52.5)

Featured Game | Nevada Wolf Pack vs. Air Force Falcons

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San Diego State vs. UNLV (+11, 41)

Featured Game | UNLV Rebels vs. San Diego State Aztecs

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Saturday, Nov. 20

Wake Forest vs. Clemson (-3.5, 55.5.)

Featured Game | Clemson Tigers vs. Wake Forest Demon Deacons

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Michigan State vs. Ohio State (-19, 66.5)

Featured Game | Ohio State Buckeyes vs. Michigan State Spartans

Iowa State vs. Oklahoma (-4, 59.5)

Featured Game | Oklahoma Sooners vs. Iowa State Cyclones

Notre Dame vs. Georgia Tech (+15.5, 59.5)

Featured Game | Notre Dame Fighting Irish vs. Georgia Tech Yellow Jackets

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SMU vs. Cincinnati (-12, 64.5)

Featured Game | Cincinnati Bearcats vs. SMU Mustangs

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Michigan vs. Maryland (+14.5, 55.5)

Featured Game | Maryland Terrapins vs. Michigan Wolverines

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Virginia vs. Pittsburgh (-13.5, 64.5)

Featured Game | Pittsburgh Panthers vs. Virginia Cavaliers

Alabama vs. Arkansas (+20.5, 56)

Featured Game | Alabama Crimson Tide vs. Arkansas Razorbacks

Baylor vs. Kansas State (pick’em, 50)

Featured Game | Kansas State Wildcats vs. Baylor Bears

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Ole Miss vs. Vanderbilt (+36.5, 64)

Oregon vs. Utah (-3, 58.5)

Featured Game | Utah Utes vs. Oregon Ducks

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Oklahoma State vs. Texas Tech (+10.5, 56.5)

Featured Game | Texas Tech Red Raiders vs. Oklahoma State Cowboys

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