No. 10 Wake Forest (9-1, 6-0 ACC) sits atop the ACC standings and will face a formidable conference opponent this weekend. The Demon Deacons will visit Clemson at Death Valley on Saturday. The Tigers (7-3, 5-2) hope to secure a fourth consecutive win after losing to No. 20 Pittsburgh. Stopping one of the top-rated passing attacks in the country will be challenging, however.

Kickoff at Memorial Stadium is set for noon ET. The Tigers are 4.5-point home favorites in the latest Wake Forest vs. Clemson odds from Caesars Sportsbook, while the over-under for total points scored is 56.5. Before making any Clemson vs. Wake Forest picks or predictions, you need to see what the red-hot SportsLine Projection Model has to say.

The model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 12 of the 2021 season on a 36-23 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Wake Forest vs. Clemson and locked in its picks and predictions. You can visit SportsLine now to see the model’s picks. Here are the college football odds and betting lines for Clemson vs. Wake Forest:

• Wake Forest vs. Clemson spread: Clemson -4.5 
• Wake Forest vs. Clemson over-under: 56.5 points 
• Wake Forest vs. Clemson money line: Clemson -200, Wake Forest +170 
• WAKE: The over has hit in six of the Demon Deacons’ last seven games 
• CLEM: The Tigers are 5-0 straight up in their previous five home games against the Demon Deacons

Why Wake Forest can cover

Only three FBS teams have more wins than Wake Forest this year. The Demon Deacons’ lone loss came against North Carolina at Kenan Memorial Stadium in a 58-55 shootout in a game that didn’t count in the conference standings. They’re 2-2 against the spread on the road, and few teams have come close to matching their firepower on offense. 

Quarterback Sam Hartman has thrown for 3,163 yards and 30 touchdowns with eight interceptions. Hartman’s also rushed for 328 yards and nine scores. Clemson’s stagnant offense has improved in recent weeks, but Wake Forest has been far more consistent. The Tigers won’t cover if they can’t keep up with an offense that’s scored 40 points in five consecutive games. 

Why Clemson can cover

The Tigers got off to a slow start but are starting to turn things around. They’re riding a three-game winning streak and have won their last two home games by double-digits. Wake Forest has a clear edge on offense, but its defense has struggled on the road. 

The Demon Deacons have given up at least 37 points in three consecutive road games. They’ve been terrible against rushing attacks on the road. Syracuse, Army, and UNC gouged Wake Forest for more than 300 rushing yards apiece. The Tigers can cover if the Demon Deacons continue to struggle to stuff the run.

How to make Wake Forest vs. Clemson picks

SportsLine’s model is leaning over on the total, projecting 57 combined points. It also has generated an against-the-spread pick that cashes in well over 50 percent of simulations. You can only get the model’s Clemson vs. Wake Forest picks at SportsLine.

So who wins Wake Forest vs. Clemson? And which side of the spread hits well over 50 percent of the time? Visit SportsLine now to see which side of the spread to back, all from the advanced model that has crushed its college football picks, and find out.