The Los Angeles Rams (7-2) and San Francisco 49ers (3-5) will meet on Monday Night Football in a matchup between bitter NFC West rivals. The Rams had their four-game win streak snapped last Sunday night in a 28-16 loss to the Tennessee Titans. The 49ers lost to the Kyler Murray-less Arizona Cardinals 31-17 and fell to 0-3 in division play. 

Kickoff from Levi’s Stadium is set for 8:20 p.m. ET. Los Angeles is favored by 3.5 points in the latest 49ers vs. Rams odds from Caesars Sportsbook, while the Over-Under is 50. Before locking in your Rams vs. 49ers picks, make sure you check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up almost $7,600 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 10 of the 2021 season on an incredible 128-88 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up!

Now, the model has simulated Rams vs. 49ers 10,000 times and just revealed its coveted NFL picks and predictions. You can head to SportsLine now to see its picks. Here are several NFL odds and betting lines for 49ers vs. Rams:

• 49ers vs. Rams spread: Rams -3.5
• 49ers vs. Rams over-under: 50 points 
• 49ers vs. Rams money line: LAR -180, SF +155 
• LAR: Under has hit in three of Rams’ last five games
• SF: 49ers are 13-4 against the spread in their last 17 Monday games

Why the Rams can cover

Los Angeles rolls into Monday Night Football with the fourth-ranked offense, averaging 399.3 total yards per game. This offensive unit is led by their air attack, which is ranked third (308.4). Quarterback Matthew Stafford has thrown for more than 300 yards passing in five games this season. 

The Rams’ best offensive performance came in Week 5 against the Seattle Seahawks, when Los Angeles finished with 476 total yards of offense. Stafford went 25-of-37 for 365 yards and one passing touchdown. The 49ers have yet to cover the spread at home this season.

Why the 49ers can cover

Tight end George Kittle returned to the field for the first time since Week 4 last week as he recovered from a calf injury. He immediately gave the offense a boost against the Arizona Cardinals and led the team with six catches for 101 yards and a score. 

Deebo Samuel is one of the top receivers in the NFL this season. Samuel is second in receiving yards (882) while reeling in a team-high 49 receptions with four touchdowns. The South Carolina product is also second in the league with 110.3 receiving yards per game. Samuel is a legitimate deep-threat weapon for San Francisco and has snagged 13 passes of 20-plus yards. Quarterback Jimmy Garoppolo has notched back-to-back 300-yard games and will look to make it three in a row against Los Angeles. 

How to make Rams vs. 49ers picks 

SportsLine’s model is leaning under on the total, projecting the teams to combine for 49 points. The model also says one side of the spread hits in over 50 percent of simulations. You can only see the model’s Rams vs. 49ers picks at SportsLine. 

So who wins Rams vs. 49ers on Monday Night Football? And which side of the spread hits in over 50 percent of simulations? Visit SportsLine now to see which side of the Rams vs. 49ers spread to jump on, all from the advanced model that is up over $7,600 on its NFL picks, and find out.